Abstract: Surgical Treatment of Breast Carcinoma Associated with Central Papillomas and PeripheralPapillomasWei LIU, Yunwei HAN, ShaoyanWEN, XinWANGCorrespondence to: XinWANG, E-mail: xinwangse@126.comThe First Department of Breast Tumors, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, ChinaAbstract Objective: To approach the clinical situation, diagnosis, treatment, and prognosis of breast carcinoma associated withintraductal papilloma ( IP ) and intraductal papillomatosis ( IPS ). Methods: Thirty-five cases of breast carcinoma from IP and 54 casesof breast carcinoma from IPS were retrospectively studied. Results: All patients were examined by mammography and ultrasonographybefore they underwent surgery. There were 20 cases of ductal carcinoma in situ and 15 cases of invasive carcinoma associated with IP,and 42 cases of ductal carcinoma in situ and 12 cases of invasive carcinoma associated with IPS. They all received breast-conservingsurgery or mastectomy with/without axillary lymph node dissection. Adjuvant chemotherapy and radiotherapy accounted for 45.71%and 59.26% in the IP and IPS groups, respectively. There was one case of positive axillary lymph nodes in the IP group and three casesof positive axillary lymph node in the IPS group. All these cases had only one positive lymph node. All patients were followed up 3-8years post-operation. Chest wall recurrence was observed in only one case, which had positive margin. Conclusion: Breast carcinomasassociated with IP and with IPS are rare and have good prognosis. Safe surgical procedures with clean margins are necessary, and senti-nel lymph node dissection is recommended.Keywords Breast carcinoma; Intraductal papilloma; Papillomatosis; Surgical treatment